Are you looking for a RAD-140 (Testolone) review? Is it an overhyped SARM?
The research drug RAD-140 (Testolone) is known to increase androgen activity in animals. There is no evidence that it is safe for human consumption, but some bodybuilders and athletes claim that it can replace exogenous testosterone replacement therapy (TRT).
Studies are being conducted on its potential benefits in treating conditions such as muscle wasting and bone loss.
RAD-140 (Testolone) is not illegal to possess, but it is illegal to sell, and it is banned in professional and amateur sports. This review summarizes scientific information made publicly available by the scientific and clinical literature.
RAD-140 (Testolone) is a dangerous experimental drug not approved for human use. Don’t take it at all.
RAD-140 (Testolone) Review – Key Takeaway
- Product Name: RAD-140 (Testolone)
- Overall Rank: 1/5
- RAD-140 (Testolone) Scam or Legit: RAD-140 (Testolone) is not a scam. However, RAD-140 (Testolone) is banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA).
- How Safe Is RAD-140 (Testolone): RAD-140 (Testolone) might be unsafe. It is a drug that has not been approved for use in humans.
- Recommended Dose: RAD-140 (Testolone) has no recommended dose yet.
What is RAD-140 (Testolone)?
Testolone, also referred to as RAD 140, is an investigational selective androgen receptor modulator (SARM) intended to replace exogenous testosterone replacement therapy (TRT).
A study conducted by the University of Southern California, Los Angeles, in 2014 showed the compound was safer than TRT.
Bodybuilders and those with low testosterone levels have become fans of this unofficial drug, even though it has not been approved by the FDA.
Testolone is believed to increase muscle-building, fat loss, physical performance effects, and sex drive. According to the World Anti-Doping Agency, it is a prohibited substance.
The post-cycle therapy (PCT) required by RAD-140 (Testolone) is the same as that required by LGD 4033, another SARM similar to SR9009.
RAD-140 (Testolone) is an experimental drug, so little is known about it. There is no FDA approval for this product and it may cause serious health problems if consumed.
Scientists are studying how this drug works in treating conditions like muscle wasting and skeleton wasting (osteoporosis) and suppressing breast cancer in mice with both androgen and estrogen receptors (AR/ER+). It may also apply to conditions like Alzheimer’s disease.
Radius Health, Inc. (RDUS) discovered and initially developed RAD-140 (Testolone) in 2003. First-in-human studies began in 2017 on patients with breast cancer. The license was then granted to Ellipses Pharmaceuticals in 2020.
After RAD-140 (Testolone) was licensed in 2020, there was a single case of liver injury caused by drug use. Once the first stage of the clinical trial is complete, more information will be available about the safety, toxicity, and potential side effects of the medication.
Is RAD-140 (Testolone) The Best SARM For Bodybuilding?
RAD-140 (Testolone) works exactly like any other SARM. Therefore, RAD140 does not have any special properties when it comes to how it functions inside the human body.
SARMs stand for Selective Androgen Receptor Modulators. Although these compounds are similar to anabolic steroids, their action is more selective. They have a set effect on specific tissues or areas as receptor modulators.
The dangers of steroids, in comparison, extend beyond muscle growth and performance. Although SARMs are a relatively new form of muscle-building drugs, they have a solid base of supporters already.
RAD-140 (Testolone) only has an edge over other SARMs in terms of how quickly it might show results. When it comes to bulking or muscle growth, RAD-140 (Testolone) may also offer better results than any other SARM.
The working mechanisms of RAD140 are similar to those of testosterone. This may enable your body to produce more protein and increase the capacity for lean muscle mass growth.
There are anecdotal reports of nausea for first-time RAD-140 users. Insomnia and lethargy are also possible side effects, and the effects vary according to the dosage and length of the cycle.
How Does RAD-140 (Testolone) Work?
RAD 140 is a selective androgen receptor modulator, or SARM. By binding to androgen receptors in the body, these receptors increase androgen activity. The androgen hormone, testosterone, androstenedione, and dihydrotestosterone, plays a critical role in male reproduction.
SARMs are thought to have similar effects on the body since they bind to the same receptors. But RAD-140 (Testolone) specifically targets the muscles, bones, and liver. Being a SARM, testolone RAD-140 is believed to have fewer side effects than testosterone or other steroids. Unfortunately, there is no evidence to support this claim.
Because of their selectivity toward these body parts, they are being investigated as potential treatments for hormone-related disorders or muscle-wasting disorders.
Since RAD-140 (Testolone) targets these specific body parts, it is a preferred choice over testosterone and steroids. Lab animals have been the main subjects of most of the tests conducted on the drug so far. Thus, its effects on humans are unclear.
Since it hasn’t been approved yet for human use, its use is generally discouraged.
By stimulating hormone receptors in the body, RAD-140 (Testolone) works biochemically. SARMs are not yet fully understood for their ability to target specific body parts. Researchers believe that RAD-140 (Testolone) activates receptors in damaged brain regions based on clinical investigations conducted on rats.
According to this study, rats exposed to the drug had increased MAPK activity in their brains, thereby protecting their neurons.
There are ongoing studies on this drug’s ability to fight breast cancer, increase muscle gain, and protect brain cells.
Treatments for osteoporosis, sarcopenia, and cachexia have also been investigated using SARMs. Their use in clinical practice, however, is not approved by the US Food and Drug Administration (FDA).
Why You Should Avoid Using RAD-140 (Testolone)
The World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA) already banned RAD-140 (Testolone) for safety concerns.
There is no good scientific evidence supporting the use of testolone in increasing energy, improving athletic performance, increasing muscle growth, or other uses. It is also possible that RAD-140 (Testolone) is harmful.
1. Report of drug-induced liver injury following use of RAD-140 (Testolone)
After taking Alpha Bolic (containing RAD-140) and Alpha Elite (containing both RAD-140) supplements, a 52-year-old man developed drug-induced liver injury.
The liver biopsy revealed that he had diffuse centrilobular canalicular cholestasis, mild lobular inflammation, prominent ductal reaction, and a rare non-necrotizing epithelioid granuloma that could be related to drug-induced liver damage.
2. RAD-140 (Testolone) is not FDA approved
The FDA issued a public advisory warning that SARMs are unapproved drugs associated with “serious safety concerns,” including the potential for liver toxicity, heart attacks, and strokes.
According to a study published in JAMA, many products marketed as SARMs were misbranded and contained unlisted ingredients. A total of 44 online products were analyzed and only half contained any actual SARMs, while 10 percent contained none. About 40 percent contained other hormones and unapproved drugs.
GlaxoSmithKline abandoned several of these drugs a decade ago after it was discovered that they caused cancer in animals.
3. The long-term consequences of using RAD-140 (Testolone) is largely unknown
It is unclear what the long-term effects of using SARMs including RAD-140 (Testolone) are, and those who buy products marketed as them are not entirely sure what they are getting into their bodies.
Many people who use RAD-140 (Testolone) combine them with other drugs, supplements, or substances, which makes it difficult to determine their exact impact.
One of the things we often see with RAD-140 (Testolone) users is worsening cholesterol profiles and rising liver enzymes, a sign of increased strain on the liver.
SARMs such as RAD-140 (Testolone) can also cause reduced sex drive, hair loss, acne, and irritability; however, it is sometimes difficult to tell whether these symptoms are due to SARMs or unlisted ingredients in the products.
Where Can You Buy RAD-140 (Testolone)?
There can be dangerous side effects associated with RAD-140 (Testolone) since it is not FDA approved. Without consulting a medical professional, we do not recommend that anyone take RAD-140 (Testolone).
RAD-140 (Testolone) is only available online in certain countries. If you want to use it for experimental purposes, you can check online stores like Amazon. All you have to do is order the quantity you need, and it will be delivered to you.
You can order the chemical from companies like Millapore Sigma and VWR if you work in an experimental laboratory. To ensure that you can legally purchase this compound for experimental purposes, you should provide a business address and documentation.
RAD-140 (Testolone) comes in a variety of brands with varying prices.
MAGNUS Testolone, Rad-140 (60 capsules/10 mg), sells on Amazon for $42 where it is legal. The capsules cost $0.70 each.
Paradigm Peptides also sells Rad 140, which sells for $79.95 (60 capsules/10 mg).
RAD-140 (Testolone) costs $243.75 per gram and $725 per gram when purchased from MilliporeSigma. Compounds of this type should only be purchased from experimental laboratories for research purposes.
RAD-140 (Testolone) Benefits
There are some potential benefits to using RAD-140, including increased energy levels, improved cardiovascular health, greater muscle gains, and the ability to lose body fat and maintain lean muscle mass.
1. Gain lean muscle mass without steroid-like side effects
Lean muscle mass can be increased with RAD-140 (Testolone) just like with traditional steroids.
By targeting bone and muscle androgen receptors specifically, RAD-140 (Testolone) carries out its anabolic activities.
It helps to increase muscle size without causing unwanted side effects such as estrogen or dihydrotestosterone production, which are associated with traditional steroids.
2. Fat loss without the side effects of steroids
RAD-140 (Testolone) provides similar fat-burning benefits to traditional steroids. In comparison to other SARMs, it functions by activating fatty acid synthase, leading to an increase in the rate at which adipose tissues store fatty acids so they can be used as energy later on in life.
3. Improved strength and muscle endurance
RAD-140 (Testolone) improves muscles’ performance by recruiting more motor units during contractions. The end result is an increase in muscle endurance, stamina, and performance levels so you get the most from your training sessions.
4. Improved mental clarity
There are also some benefits for cognitive function and mental clarity with RAD-140 (Testolone). This drug has been shown to increase task flexibility, working memory, and reaction time.
RAD-140 (Testolone) Dosage
As RAD 140 is not a pharmaceutical, no dosage guidelines are available since it does not have FDA approval.
Men, however, typically take 10-20mg/day for 6-12 weeks to improve body composition.
For women, RAD 140 is normally taken at the same doses for the same length of time, allowing them to experience the benefits of RAD 140, without any masculinizing side effects (typical of steroid use).
RAD 140 is typically available as a liquid solution or capsule of 10mg.
RAD-140 (Testolone) – Before and After Results
As per user reviews, RAD-140 (Testolone) is considered a unique SARM that delivers excellent results. Its distinctiveness stems from the fact that it can be used for both bulking and cutting.
Though many SARMs provide quick gains, users report most of the gains as bloating. The bloating or fake gains fade away as soon as the user stops using those SARMs.
Users of RAD-140 (Testolone) have noted that while the gains are not as strong as other SARMs, the gains are still solid and consistent. It means RAD-140 (Testolone) Testolone is helping users build more permanent muscle mass.
A few weeks after using RAD-140 (Testolone), users will generally notice an increase in lean muscle mass and fat loss as well. Due to RAD 140’s lack of water retention, your increased muscle mass will actually help you to burn calories, which in turn will result in better fat burning.
In most cases, new users are curious to know what results can be obtained by using RAD 140 SARM. Depending on the user’s experience, a cycle can produce anywhere between 8 to 15 pounds. Average linear weight gain is approximately 10 pounds, but this includes both lean tissue and body fat.
Besides growing in size, most of the users reported an improvement in strength. The problem is that to maintain all these great results and gains, you need to follow a good post cycle therapy protocol. Otherwise, you may lose a great deal of your progress.
Testolone is a powerful and suppressive SARM. Once the treatment is over, your body’s natural T-levels will be slowed down, so you will have to take a potent PCT supplement to replenish them.
RAD-140 (Testolone) Side Effects
The use of RAD-140 (Testolone) in animal studies has shown that it is safer than testosterone replacement therapy. In light of testosterone’s generally favorable safety profile, hence its FDA approval, this is impressive.
RAD-140 (Testolone), however, appears to cause more severe side effects in humans.
1. Liver Toxicity
Research shows that RAD-140 (Testolone) can cause hepatocellular–cholestatic liver injury, despite its recent formulation.
In the report of liver toxicity, a 49-year-old man took RAD-140 (Testolone) continuously for four weeks, followed by intermittent use afterwards. In addition to RAD 140, he was also taking an antidepressant (venlafaxine), which he had been taking for 11 months.
Although this man’s alcohol consumption was insignificant, the combination of SARMs and hepatotoxic antidepressants may prove lethal – even if otherwise leading a healthy lifestyle.
Based on his analysis of more than 2,000 patients taking SARMs over a decade, Dr. Thomas O’Connor compared SARMs to taking 50mg/day of anavar.
The oral route of entry of RAD-140 (Testolone) is likely to be responsible for such hepatic stress.
Similar to c-17 alkylated oral steroids, it bypasses the liver upon entering the bloodstream, resulting in excessive workload on the organ.
2. Increased Blood Pressure
RAD-140 (Testolone), as well as other SARMs, increase the risk of atherosclerosis and myocardial infarction through a dose-dependent negative effect on cholesterol.
As SARMs pass through the liver, they stimulate the hepatic lipase enzyme, causing HDL cholesterol levels to drop. High levels of HDL cholesterol are beneficial for heart health because they reduce arterial plaque.
Testolone’s lack of aromatization may be another contributing factor to undesirable blood lipids. Some anabolic steroids, however, do convert to estrogen, causing a smaller change in cholesterol levels. This is due to the positive effect estrogen has on HDL levels, so inhibiting this conversion is not beneficial to heart health.
3. Testosterone Suppression
In a similar manner to anabolic steroids, RAD-140 (Testolone) inhibits testosterone production through its aggressive binding to the androgen receptor.
Anecdotal evidence suggests that suppression is significant, although the extent of the problem has yet to be determined.
RAD-140 (Testolone) may cause clinical hypogonadism through the HPTA (hypothalamic-pituitary-testicular axis), which may affect users’ long-term fertility.
There is no doubt that all SARMs suppress endogenous testosterone, however the effect of RAD-140 (Testolone) seems to be more pronounced than other SARMs because it is a more potent compound.
4. Gynecomastia & Water Retention
RAD-140 (Testolone) does not aromatize, but it can still raise estrogen levels in a different way. In an attempt to bind to the androgen receptor, SARMs compete with a user’s natural testosterone. These hormones are raised when SARMs are used due to their superior binding affinity, which allows free testosterone to convert to estrogen and DHT (dihydrotestosterone).
The high levels of estrogen in RAD-140 (Testolone) can cause water retention, bloating, and gynecomastia, so having an AI (aromatase inhibitor) nearby could be a good idea.
5. Hair Loss & Prostate Enlargement
In animal studies, RAD-140 (Testolone) has been shown to be an effective treatment for benign prostatic hyperplasia, due to its tissue selectivity and the resulting shrinkage of the prostate.
To replicate testosterone-induced prostatic hypertrophy, RAD-140 (Testolone) required a dosage 60x higher than that of testosterone in rats.
Testolone users have however reported instances of hair loss, which could be related to increased levels of natural testosterone converting into DHT, since it no longer binds to AR.
The higher the DHT levels, the more inflammation and miniaturization of the scalp hair.
When hormones return to normal after a cycle of using RAD-140 (Testolone), such shedding may reverse. Long-term use and sustained high levels of DHT, however, increase the risk of androgenic alopecia.
Acne vulgaris can also occur due to increased sebum production, causing sensitive users to experience the condition.
According to animal studies, RAD-140 (Testolone) should not result in androgenic side effects due to its tissue selectivity. However, its indirect effect on natural testosterone and its conversion to DHT pose problems in practice.
Is RAD-140 (Testolone) Safe?
RAD-140 (Testolone) is not a safe drug.
Even though RAD-140 (Testolone) does not exhibit severe anabolic steroid side effects, it still contains a powerful chemical that has a very “dynamic” composition.
In other words, it can offer benefits, however, it can also have many side effects, which are milder and less severe than steroids, but are just as predictable as well.
Despite their long study history, SARMs including RAD-140 (Testolone) have not received FDA approval, even for conditions where the benefits might outweigh any significant risks.
In fact, it is mostly anecdotal evidence, not scientific evidence, that SARMs such as RAD-140 (Testolone) enhance performance and are generally safe.
Studies have found that SARMs pose serious health risks, such as heart attack, stroke, and liver damage.
Is RAD-140 (Testolone) Legal?
RAD-140 (Testolone) is legal to own, but it is illegal to sell, and it is banned from professional and amateur sports.
RAD-140 (Testolone) is a drug that is still in its preclinical testing stages and has not yet been approved by the FDA. It is only available to purchase for medical and scientific purposes, and not for recreational use.
In other words, a SARM such as RAD-140 (Testolone) marketed as a research chemical can legally be sold and bought online. If packaged in capsules for human consumption and/or labeled as dietary supplements, it is illegal to sell and buy them.
RAD-140 (Testolone) Post-cycle Therapy
The binding affinity of RAD-140 (Testolone) to the AR causes it to suppress testosterone by lowering FSH and LH levels.
The testosterone levels of some RAD-140 (Testolone) users have been found to be suppressed post-cycle, causing them to undergo post-cycle therapy (PCT).
Due to its short half-life (60 hours), RAD-140 (Testolone) users can begin a PCT five days after completing the cycle.
Typically, clomid or nolvadex are taken in order to restore endogenous testosterone, with nolvadex being the stronger medication. As a result, clomid may be sufficient for a PCT when stacked with RAD-140 (Testolone), but nolvadex may be more effective when stacked with another SARM.
Clomid is typically taken at 25 mg/day for 30 days, or 20 mg/day of nolvadex for 30 days, during a RAD-140 (Testolone) PCT.
Since the duration of a PCT cycle can be influenced by the strength and dose of the SARM used, it can be difficult to determine how long it should last.
We do not know the potential adverse effects of cycling SARMs with PCT supplements until there is concrete clinical data.
Legal RAD-140 (Testolone) Alternatives
With all the information and facts about RAD-140 (Testolone), we would definitely not recommend taking it. It’s still under testing, so we aren’t sure of any long-term side effects, which means it may be dangerous.
However, if you are really interested in SARM, you might consider checking out its legal alternatives. They are manufactured in an FDA-registered facility in the United States.
RADBULK is a legal alternative to RAD-140 (Testolone). In RADBULK, a blend of 5 natural ingredients work synergistically to provide the ideal hormonal support for increasing lean muscle mass quickly.
Currently in Phase 1 trials for treating muscle wasting, it is one of the most popular selective androgen receptor modulators on the market.
RADBULK is a selective androgen receptor modulator that is commonly used by athletes for its innate ability to promote muscle recovery and burn fat at the same time.
Its versatility also contributes to its popularity. Both cutting and bulking cycles can be completed using this SARM.
You can increase muscle mass with it when you eat a calorie surplus. You can also burn fat while doing this. If you switch to a cutting cycle, you will be able to preserve more muscle tissue.
In contrast to the testosterone-suppressing effects of RAD-140 (Testolone), RADBULK does not affect androgen receptors and will not produce the same adverse effects. This means no PCT supplement is required.
YKBulk is one of the best SARMs for overall gains. As a bulking SARM, it is most effective in increasing muscle mass quickly. In addition, the reduction of Myostatin and the increase in androgen levels helps to burn fat.
RAD-140 (Testolone) was expected to be the strongest of all the SARMs when it was launched. With YK 11, record-breaking gains in strength and mass were achieved.
In contrast to testosterone, YK11 binds to the muscles’ androgen receptors 10 times more strongly than it does testosterone.
It does not modulate androgen receptors selectively. Instead, it inhibits myostatin production, causing follistatin levels to increase.
As with any strong compound, there are severe side effects as well. Like anabolic steroids, YK 11 can shut you down completely. Therefore, Brutal Force created YKBulk, the legal alternative to YK11.
YKBulk does not contain banned ingredients or doping compounds that are prohibited by the world anti-doping agency.
In general, however, YKBulk is not recommended for beginners, due to the intense boost in strength and size.
Watch the video below if you want to find out more SARMs that are safer than RAD 140 (Testolone).
RAD-140 (Testolone): Final Words
RAD 140 (Testolone) is a potent SARM that enhances muscle-building, strength and fat loss; with unique tissue selectivity. However, there does appear to be steroid-like risks associated with this SARM, particularly liver toxicity and cardiovascular strain.
Such deteriorations in health are evident in human trials and backed up by Dr. Thomas O’Connor’s vast experience of treating men and women on RAD 140 for a decade.
With harsh negative effects occurring, with minimal results in muscular hypertrophy, RAD 140 may present a higher risk vs reward ratio, compared to mild anabolic steroids (such as testosterone or anavar).
Dr. O’Connor believes SARMs, such as RAD 140, are actually more dangerous than anabolic steroids, following regular analysis of 2,000+ patients’ labs. Thus, we must warn any of our readers thinking about experimenting with SARMs, that they are unlikely to be as safe as originally thought.
RAD-140 (Testolone) FAQs
Is RAD-140 (Testolone) dangerous for the prostate?
Since RAD-140 (Testolone) is selective for muscle and bone, it does not convert to dihydrotestosterone, so it is not harmful to the prostate like anabolic steroids.
Are cortisol levels increased by RAD-140 (Testolone)?
Rad140 is not known to affect cortisol levels in the body or to increase its production.
Is RAD-140 (Testolone) banned from sports?
In the WADA “Prohibited List”, RAD140 is classed as a S1 anabolic agent.
Does RAD-140 (Testolone) lower testosterone?
Testosterone production is suppressed by RAD140, but at a considerably lower level than some anabolic steroids. Furthermore, the size of the dose and the length of use have an impact on the reduction of testosterone production.
Does RAD-140 (Testolone) increase DHT?
RAD-140 (Testolone) does not produce estrogens or DHT. It has no steroid structure, so reductase and aromatase enzymes (which are responsible for converting androgens to DHT and estrogens), cannot attach to it.
Is RAD-140 (Testolone) more powerful than testosterone?
LGD-4033 and RAD-140 (Testolone) SARMs are considered by bodybuilders to be more effective in the building of muscle mass than testosterone because they can achieve massive muscle gains that are comparable to those of bulking steroids.
What is the half life of RAD-140 (Testolone)?
The half-life of RAD-140 (Testolone) in humans is not known since no clinical studies have been conducted in humans. RAD-140 (Testolone), however, is estimated to have a half-life of 24 hours in humans.
Do you get gyno from RAD-140 (Testolone)?
The risk of RAD-140 is much lower than that of anabolic steroids. Gynecomastia can, however, be triggered by a hormonal imbalance caused by suppression of testosterone production.
Is RAD-140 (Testolone) a steroid?
RAD-140 (Testolone) is not an anabolic steroid. It is an investigational Nonsteroidal selective androgen receptor modulator (SARM).