Jarrow Formulas SAM-e 200 Review – Scam? Ingredients Exposed!

Are you looking for a Jarrow Formulas SAM-e 200 dietary supplement review? Is Jarrow Formulas SAM-e 200 dietary supplement a scam? 

There are millions of Americans who take vitamins or supplements every day, so you’re not alone. In addition to a healthy diet, there is evidence that some supplements can benefit your overall well-being with little to no risk.

Sadly, the supplement industry is also home to plenty of scammers who spread misinformation to hype questionable products and lure the unwary with deceptive marketing strategies.

It doesn’t matter whether you’ve been scammed yourself or if you would like to learn more, our reviews will give you the knowledge you need to spot and avoid scams with more confidence.

We have researched the brand Jarrow Formulas SAM-e 200 thoroughly in the past week to determine if it is a good supplement or just another waste of money. 

In this Jarrow Formulas SAM-e 200 review, we’re going to cover the following to help you make an informed decision.

What is Jarrow Formulas SAM-e 200?

Jarrow Formulas SAMe 200 provides a full 200 mg SAMe (net yield) from 400 mg of SAMe tosylate disulfate. SAMe 200 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

SAM-e exists in two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is inactive. 

SAM-e is a highly reactive molecule and very fragile. It degrades rapidly under high heat or humidity. Improper handling of SAM-e can cause degradation in a matter of hours. Thus, the manufacturing process for Jarrow Formulas SAM-e is done under low temperature and low humidity, and the tablet is enteric coated and blister-packed. Pharmacokinetic studies show that oral supplementation of SAM-e is most effective when enteric-coated by special gastric fluid-resistant polymers, resulting in maximum blood levels.

Jarrow Formulas SAM-e is predominantly the active form. It is made naturally by microbiological fermentation and then specially processed, without solvents, to preserve 68-80 percent (S,S) SAM-e, the highest active level available.

How Does Jarrow Formulas SAM-e 200 Work?

Joint Health

SAMe supports the production of healthy connective tissue through transsulfuration. In this process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.

Brain Metabolism and Mood

SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the brain and cellular membranes and precursor to acetylcholine, as well as neurotransmitters such dopamine, norepinephrine, and serotonin, and has been shown to have a positive effect on mood.

Liver Function

SAMe metabolism supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.

Energy Production

Methylation from SAM-e is also critical for creatine production. Creatine metabolites are important for ADP to ATP recycling and storing energy for immediate needs. Supporting creatine levels may help maximize physical performance, reduce exercise fatigue and improve recovery after exercise.


A healthy young body manufactures all the SAM-e it needs. However, with age, people are less able to produce adequate SAM-e. This may contribute to declining health on many levels. Fortunately, these disturbances are often boosted by SAM-e supplementation.

In addition, methylation of DNA is an important part of DNA repair. De-methylation of DNA contributes to the aging process. Proper methylation, via substances such as SAM-e, positively influences longevity.

Why Choose Jarrow Formulas SAM-e 200?

Formulating Health for Decades

Since our founding in 1977, Jarrow Formulas’ mission has always been to put science first. Jarrow Formulas believe that dietary supplement formulations based on relevant and strong scientific research have the potential to support and promote optimal health. That’s why they participate in and support scientific research around the world.

Purity and Potency

Jarrow Formulas products are manufactured in Current Good Manufacturing Practices(cGMP) certified facilities. Under cGMP regulations, manufacturers are required to evaluate the identity, purity, strength, and composition of ingredients. 

And Jarrow Formulas only work with raw material suppliers that follow these practices as well. Jarrow Formulas customers can be assured of purity and potency when choosing from our comprehensive dietary supplements line.

Quality Testing from Start to Finish

Jarrow Formulas in-house analytical laboratories enable our staff of highly trained specialists to test our products’ quality from start to finish. 

Jarrow Formulas analyzes raw materials for identity, chemical, microbiological, heavy metals, organoleptic, and other physical properties prior to manufacturing. But they don’t stop there. Finished products are also tested to ensure they meet the highest quality standards.

How To Use Jarrow Formulas SAM-e 200?

Take 1 tablet 1 or 2 times per day on an empty stomach or as directed by your qualified healthcare professional.

Jarrow Formulas SAM-e 200 Customer Reviews

As with any supplement, Jarrow Formulas SAM-e 200 has received both positive and negative feedback from customers. The effects can vary from person to person, after all.

Positive Jarrow Formulas SAM-e 200 Feedback

“1 month review: This works, it lifts the mood. I no longer feel “the pit of doom”. Let me explain, as a formerly depressed individual I would quite often struggle at dealing with negative emotions. The day to day grind would really get to me, I would hate my job and feel depressed at knowing I didn’t have the energy to find a new one. Every bad thing that happened to me would create this pit of doom. It didn’t matter if I tried to be positive about it, the pit of doom was always there.

In comes SAM-E, 40min after having taken the first tab I had a tremendous amount of energy and the pit of doom vanished. I tried to think of negative things, but nothing left me feeling depressed, instead SAM- E left me feeling motivated to take action. After the first week it would make me feel sleepy so I began to cycle it every other day.

I’m currently taking half of the tab every other day and feel good.

Reason for it working: I took a 23andme DNA test which informed me I had poor methylation. I read into this and began to supplement with easily absorbable forms of B12, B9, and magnesium.

I don’t think all forms of depression have the same cause but if you are also a poor methylator then SAM-E supplementation may cure you.

Plus it’s only $20…and if you take too much you’ll finally understand why some people are always hyper, overmethylation. I would recommend to buy Niacin along with this just in case 200mg of SAM-E is too much. Niacin eliminates the benefits of SAM-E so only take a little bit.” by Joe Ronaldino

“Wow. Just wow. I purchased this product with zero expectations. Come to think of it, I don’t even remember where I learned about SAM-e and it’s potential to help ease depression symptoms. I have (had?) fibromyalgia and was waking up every day since July of last year with the worst headaches and body aches imaginable. I had consistent brain fog that involved not remembering how to speak because I would have an inability to remember my internal vocabulary to form a sentence. I was seriously scared that I was going to lose my job. I started feeling depressed because I thought my entire life was going to be taken away from me due to this very misunderstood illness. I had purchased this brand of SAM-e last year and neglected to take it for more than a couple days because I honestly didn’t think it would work. I was on my last leg and seriously ready to just give up everything when I decided to start taking them March 1st of this year. What harm could it do? I did my research on Clinical Pharmacology and figured the risks were fewer than the potential reward. All I can say is… wow. I never thought they would work as well as they do. After five days I noticed an immediate difference upon waking. I felt the fog lift literally and I could finally speak clearly at work. Every day I woke up, it felt easy. I no longer had pain. I no longer woke up with pounding headaches. I felt like I actually had refreshing sleep for the first time in months. I literally felt like a new person. After taking them for almost a month, I feel more confident in my ability. I’m going out and doing things more and taking more risks, and I feel my mood has been lifted. I do not feel like a zombie at all and I have a smile on my face most of the time. I have a history of depression so this is very odd for me. I would recommend this product to anyone that is having similar issues to what I was experiencing. I have no idea why it works but I know that it does and it saved my life and career. As for dosing, I started taking only one tablet once daily (200mg) in the morning with some water. After two weeks, I noticed that I had a slight headache upon waking again so I upped it to 400mg in the morning daily. You are supposed to take it on an empty stomach. I have been taking 400mg in the morning for the last two weeks and I still have the same great results. From my research, it is postulated that B vitamins are necessary to fully absorb the active ingredient, so I started taking a multivitamin every morning after I eat breakfast (after taking the SAM-e as soon as I wake up.) I have never experienced stomach pain from taking SAM-e. I am speculating that whatever neurotransmitter is being produced as the result of taking SAM-e is helping me sleep better at night. I get very tired very suddenly around 10pm every night since I have been taking SAM-e and I think it helps me get more refreshing sleep, which as a result means I wake up not feeling like I got hit by a bus. Take what you want from my review, but it seriously changed my life and I feel like I can accomplish everything I wanted out of life now. I hope my review can help someone else that is struggling from similar things that I was. I will update this post after I have taken SAM-e for six months.”  by pathetiquehumor

Negative Jarrow Formulas SAM-e 200 Feedback

“I purchased this item about 3 weeks ago and I have mixed feelings on it. I want to state that the reason I was taking it was for mood. I was really hoping to find a more natural approach to antidepressants and my doctor mentioned this product. The first few days I started to feel a little better but nothing too dramatic but I figured if after only a few days it was doing this that it would continue to get better.

It actually made things worse the longer I took it. I started to feel cloudy mentally and couldn’t focus. It also made me extremely sleepy as well. I’m not saying that this caused it but I started to get a swollen eye with twitching and thick tears but I was experiencing a lot of stress and is possible allergies could also have played a part.

I stopped taking it after about a little over two weeks because it wasn’t helping enough to deal with the side effects I was experiencing. My advice is if you start feeling any of this within the first few days to discontinue use. Even after several days being off of it I’m still not feeling right so look up side effects on forums and any other sites you can find before considering this alternative. I didn’t see a lot of the complaints on here that I found elsewhere.

I gave it 3 stars because it does help some people and just like antidepressants everyone reacts differently so Just be careful. Worth noting this product is more bio available than most so your body processes it better and is more potent so that’s a plus. Just because my experience was unsatisfactory doesn’t mean yours will be too, just weigh all options first and do your research.” by B-Mackin

“I have been depressed for a year and dont believe in antidepressants. Since Dr Oz recommended this supplement I decided to try it. I do think my mood has improved a little bit since I started taking it and I’m hoping it continues to improve. It’s really hard to tell what supplements do for you.” by newyearforme

Jarrow Formulas SAM-e 200 Precautions

Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product. Individuals with Parkinson’s disease, bi-polar disorder or manic depression should not use SAMe. 

Do not use it if pregnant or nursing. Do not exceed recommended intake. 

May cause gastrointestinal upset in some persons. Consult a healthcare professional before using this product if you are trying to conceive, under the age of 18, or have a medical condition; if adverse reactions occur, discontinue use.

Jarrow Formulas SAM-e 200 Return Policy

If you are dissatisfied with an Eligible Product in any way, within sixty (60) days of the date of purchase of the Eligible Product, you may return the Eligible Product and request any one (1) of the following: a) a full refund of the purchase price, b) a credit in the amount of the purchase price redeemable for purchases made on the website or Jarrow Formulas®’ web pages linked to our website or c) replacement of the Eligible Product.

To request a refund, credit, or replacement of an Eligible Product, please email [email protected] for a return authorization. 

After receipt and review of the information provided above, Jarrow Formulas® Credit Department will issue a return authorization and email further instructions, which will include shipping information so that you can return the unused portion of the Eligible Product to them. 

In general, any Eligible Product may be returned previously opened and/or without its original seal. However, in order to qualify for a refund, credit or replacement, the returned Eligible Product must not be missing more than thirty (30) days’ worth of the Eligible Product’s serving size as noted on the label and must be returned with the original packaging[, including any ice packs included with such packaging].

Jarrow Formulas® will reimburse customers for all standard shipping and handling fees for the return of Eligible Products. Customers shall not be responsible for shipping and handling costs for replacement of Eligible Products.

Jarrow Formulas SAM-e 200 Contact Information

Jarrow Formulas is open Monday through Friday. The customer service department is available to serve you from 8:00 am until 5:00pm PST.


(310) 204-6936


(310) 204-2520


1818 S Robertson Blvd

Los Angeles, CA 90035

Questions / Comments

[email protected]

Jarrow Formulas SAM-e 200 Ingredients

Jarrow Formulas SAM-e 200 has a unique formula. The product was created with natural ingredients and scientific backing. You can achieve the promised benefits by using the Jarrow Formulas SAM-e 200 on a regular basis.

Below is a list of the ingredients in Jarrow Formulas SAM-e 200.

S-Adenosyl Methionine (from 400mg of SAMe tosylate disulfate), Cellulose, mannitol, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, sodium starch glycolate. Enteric coating consist of modified cellulose, triethyl citrate, magnesium silicate, titanium dioxide, silicon dioxide and riboflavin.

Final Verdict: Jarrow Formulas SAM-e 200 Reviews

Customers have given Jarrow Formulas SAM-e 200 positive reviews, but you should still speak with your healthcare provider before starting a new dietary regimen. Many supplements on the market have various ingredients and fillers. They can have side effects and may interact negatively with drugs. Therefore, you need proper guidance from your doctor to help you make the right decisions.

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