Are you looking for a Cardarine (GW501516) review? Is it a dangerous drug?
Bodybuilders and fitness enthusiasts are quite familiar with compounds like Cardarine, which help them achieve rapid results. Commonly mistaken for a SARM (Selective Androgen Receptor Modulator), Cardarine is a compound that is not exactly like that.
It is important to note that Cardarine, or GW 50156, is a research compound, not yet approved for human consumption by the FDA.
Cardarine is currently classified as an illegal substance for human consumption. Cardarine’s supposed benefits have not been documented or substantiated. It was also discovered that Cardarine could cause cancer during its research prior to clinical trials.
This compound is incredibly dangerous, and should be avoided at all costs. We have gathered the following information about Cardarine (GW501516) from current clinical and scientific research papers.
Cardarine (GW501516) Review – Key Takeaway
- Product Name: Cardarine (GW501516)
- Overall Rank: 1/5
- RAD-140 (Testolone) Scam or Legit: Cardarine (GW501516) is not a scam. However, it is banned by the World Anti-Doping Agency (WADA).
- How Safe Is Cardarine (GW501516): Cardarine (GW501516) might be unsafe. It is a drug that has not been approved for use in humans.
- What is Cardarine (GW501516) For: Cardarine (GW501516) is used for weight loss, to treat diabetes, to improve athletic performance, and for other purposes, but no scientific proof supports its use. It might also be harmful.
What is Cardarine (GW501516)?
Cardarine, also known as GW 50156, is often referred to as a SARM (Selective Androgen Receptor Modulator). However, this is not the case, as both GW 50156 and Endurobol are PRAR (Peroxisome Proliferator-Activated Receptor) agonists. In its original formulation, this drug was intended to treat both metabolic and cardiovascular conditions.
Recent research has revealed that this compound could potentially increase performance and capacity. Cardarine has been shown in clinical studies to help increase endurance and improve cardiovascular health overall. It also increases your ability to perform like a beast during workout sessions and helps with fat loss.
In the 90s, Ligand Pharmaceuticals and GSK developed GW 50156 Sarms to treat diseases such as diabetes and cardiovascular issues. LGD 4033 was also developed by LGD Pharmaceuticals.
A study published in 2007 showed that high doses of GW501516 dramatically improved mice’s physical performance; the work was widely reported in the media, which led to the development of a black market for the drug candidate and its abuse by athletes.
GSK abandoned further development of the drug in 2007 after GW501516 had completed two phase II clinical studies and other studies on obesity, diabetes, dyslipidemia and cardiovascular disease. The reasons for abandoning the drug were not disclosed at the time.
Upon further review, it was revealed that the drug was discontinued because animal testing showed that at dosages of 3 mg/kg/day, both mice and rats developed cancer rapidly in several organs.
Despite Cardarine’s unapproved status due to safety concerns, bodybuilders and athletes use it for its incredible fat loss and endurance benefits.
Shortly after Cardarine was introduced to the market, WADA (World Anti Doping Agency) added it and other PRAR receptor agonists to its list of banned substances.
Cardarine’s advocates claim there have only been animal studies on cancer risk but no human studies to date. In response, the science community said that the compound must first be proven safe in order to conduct a human study, which has not been the case yet.
The video below gives you an overview of Cardarine (GW 50156).
Is Cardarine A SARM?
It may have been found on some sites that Cardarine is classified as a selective androgen receptor modulator (SARM). Since Cardarine does not target androgen receptors, it cannot be classified as a SARM.
Cardarine (GW501516) acts as an activator of PPAR-delta, whereas SARMs stimulate muscle growth by activating androgen receptors in bone and muscle tissues.
How Does Cardarine (GW501516) Work?
As mentioned earlier, Cardarine is an agonist of the PRAR receptor, which means that it binds to PRAR receptors to initiate a biological response. By activating PPAR, the liver reduces the liver glucose output, resulting in improved glucose tolerance and insulin sensitivity.
PPAR delta is a hormone receptor that regulates many biological processes. In addition to helping to absorb cholesterol and fat, it facilitates the growth of intestinal mucosa in response to fat. Furthermore, PPAR delta reduces inflammatory responses of macrophages and is associated with elevated HDL cholesterol levels.
Following are the main mechanisms by which Cardarine binds to the PRAR receptor:
In skeletal muscle, cardarine activates AMP-activated protein kinase, glucose uptake, and fatty acid oxidation.
By inhibiting fatty acid oxidation, promoting fat burning and increasing glucose uptake in muscle tissue, cardarine may help obese and pre-diabetic individuals reverse metabolic abnormalities. This causes the body to burn fat for energy rather than muscle or carbohydrates.
In turn, the user might experience further fat loss and a massive increase in endurance levels as a result of increasing oxidative capacity in muscles.
Therefore, people who promote the use of Cardarine despite the danger, claiming that it may:
- Protect the brain and blood vessels.
- Enhance athletic and/or physical performance by burning more body fat.
- Improve insulin sensitivity and lipid profiles.
In the scientific community, those with clinical experience are emphatic about Cardarine’s risks, including but not limited to:
- Cardarine is banned for being a carcinogen.
- Clinical studies on humans are virtually nonexistent.
- It can cause liver damage and aggravate liver disease.
- Complications and impairments in a developing fetus.
- Brain damage is an increased risk.
Cardarine (GW501516) Benefits
Cardarine (GW501516) was primarily developed to treat obesity, diabetes, lipid strain, and heart problems. According to some studies, it promotes fat loss, increased energy, and increased endurance.
Cardarine (GW501516) might reduce overweight and obesity
As a possible solution for preventing obesity, researchers began studying Cardarine (GW501516). Cardarine was found to be effective at reducing metabolic syndrome in obese monkeys with increased cholesterol.
According to the study, the subject’s liver fat decreased by 20%, insulin decreased by 11%, and their levels of triglycerides, VLDL and LDL dropped by 20%.
Moreover, in a study of mice treated with cardarine, there was a lower production of glucose in the liver as well as a greater sensitivity to insulin.
Cardarine (GW501516) might enhance muscle Growth and endurance
Through activating scripted changes in gene expression, endurance training can stimulate adaptive muscle fiber transformation and mitochondrial synthesis. To date, no transcription factor has been identified that controls this process in humans.
A study in mice showed that Cardarine (GW501516) activated PPAR delta, which improved muscle fiber development. By continuously running for long periods, the mice were able to increase the number of types of muscle fibers in their bodies, which resulted in this targeted expression.
Although they were not exercised, the new muscle fibers proved more resistant to obesity and perfected their metabolic profiles. In addition, mice that developed new muscle were able to run more than twice as long as regular mice and exhibited improved endurance abilities as a result.
Is Cardarine (GW501516) Safe?
Cardarine (GW501516) can’t be deemed as a safe drug.
There is insufficient clinical data on GW501516’s safety to assess the long-term health risks it may pose to human subjects. Because there have been few clinical trials, the long-term consequences have not yet been discovered.
The effects of cardarine (GW501516) on lipid and lipoprotein metabolism have been studied in clinical trials. No significant adverse effects were observed in the human studies, which might be explained by the significantly lower doses administered (up to 10 mg/day) for much shorter periods of time (up to 12 weeks).
Having said that, WADA took the unusual step of warning athletes about the possible health risks associated with using Cardarine (GW501516) for performance enhancement in 2013.
According to WADA, in preclinical studies, the pharmaceutical company discovered serious toxicities in Cardarine (GW501516) and withdrew it from research.
The New Scientist attributed the warning to the risks of the drug causing cancer.
Is Cardarine (GW501516) A Scam?
Cardarine (GW501516) cannot be called a scam because there are only a limited number of human studies.
The fat-burning potential of cardarine was one of the main factors that attracted researchers. Cardarine (GW501516) was already known to activate PPAR-delta, which consequently activates several genes related to fat burning and increased energy.
The fat-burning effects of Cardarine (GW501516) were recently examined in a very small human study (fewer than 15 subjects). There were men who had high cholesterol in that study, as well as significant belly fat storage. For 6 weeks, the subjects were given 2.5 mg of cardarine per day.
The subjects in the study had reduced their levels of triglycerides, fatty acids, as well as their levels of VLDL, a low-density lipoprotein that is similar to LDL.
Following that, a small human study examined l-carnitine’s fat burning and energy-boosting effects. Researchers found that l-carnitine’s fat burning and energy enhancing effects were superior to Cardarine’s.
According to the researchers, Cardarine (GW501516) provides some low-quality fat burning and reduces blood fats, but the risks associated with its use far outweigh any of its purported benefits.
Cardarine (GW501516) Side Effects
In a series of studies and researches conducted on this compound, it has been discovered that it accelerates the development of cancerous tumors.
Cardarine (GW501516) was found to accelerate the development of cancerous tumors in rats in a 2007 study conducted by GSK.
People are skeptical about this study due to the use of absurd dosages and long cycle periods with GW 50156.
However, we should not overlook the risks (see below) that Cardarine (GW501516) might pose to users’ health.
1. Cardarine (GW501516) Might Damage Brain Cell
In a first animal study, Cardarine (GW501516) was tested to see if it could reduce oxidative stress in the brain. Cardarine was initially shown to improve blood circulation and decrease oxidative stress in mice.
While the initial results appeared promising, Cardarine was found to have pro-inflammatory effects on the animal brain cells. Cardarine, for example, lowered certain inflammatory cytokines such as TNF (Tumor Necrosis Factor), but increased others such as IL-6 (Interleukin 6), which can damage brain cells at elevated levels.
Study findings concluded Cardarine’s potential to reduce oxidative stress was quickly negated by its high potential for brain damage.
2. Risks of Using Cardarine (GW501516) on Heart and Kidney Health
Researchers found that lower doses of Cardarine (GW501516) reduced inflammation and tissue damage in mice’s arteries and blood vessels. They investigated whether Cardarine could reduce the risk of heart disease and its complications following this discovery.
Cardarine (GW501516) was found to inhibit oxidative damage to blood vessels in studies conducted on mice. In addition, Cardarine was supposed to increase nitric oxide production, thereby lowering plaque buildup in the arteries. A low dose of Cardarine also reduced inflammation and tissue damage in mice’s arteries.
In the laboratory, Cardarine (GW501516) stimulated blood vessel growth in human heart cells. It could be helpful if you have heart disease, but it may be excessive if you are healthy or if you have a propensity to develop cancer.
Prior to the administration of Cardarine (GW501516), kidney inflammation was measured in the mice. An increasing number of genes associated with kidney disease were lowered after a small dose of Cardarine was given to the mice.
3. Cardarine Might Cause Liver Damage
Cardarine (GW501516) was studied primarily for its liver effects. The liver is the most important organ for the burning, releasing, and storing of fat in the body. Through PPAR-delta, the liver is prompted to shift its energy source from glucose to fatty acids, thereby reducing blood sugar levels.
According to preliminary studies conducted on mice and cells, Cardarine (GW501516) showed promise as a potential liver health supplement. Cardarine was found to lower levels of cytokines in liver cells, which is believed to prevent insulin resistance. In mice fed a high fructose diet, the amount of liver damage caused by Cardarine was lower, as were the chances of developing fatty liver disease.
Cardarine (GW501516) was, however, shown to cause the death of liver cells and fibrosis in a relatively short time, advancing the argument that the compound was too dangerous for human studies.
Is Cardarine (GW501516) Legal?
It is important to know the legal status of any compound or drug before using it. In every country around the world except Australia, Cardarine (GW501516), is legal to buy and use as of June 2020. However, in professional sports, Cardarine is not legal.
Cardarine (GW501516) is usually sold under the label “Research chemical” or “Not for human consumption”. The FDA (Food and Drug Administration) has not approved it for human consumption. However, this has nothing to do with Cardarine’s legal status.
Due to the TGA’s Schedule 9 designation, Cardarine is considered an illegal substance even with a doctor’s authorization. SARMs and MK 677, on the other hand, are permitted in Australia provided that a doctor’s prescription is obtained.
For professional athletes, Cardarine or GW 50156 is considered a prohibited substance by almost all sports associations. In addition, Cardarine is not allowed in the Olympics due to the obvious unfair advantage it can give in terms of better endurance and stamina.
In addition to WADA, GW 50156 is also listed as a banned compound by the USADA (the United States Anti-Doping Agency) and ASADA (the Australian Anti-Doping Agency).
Cardarine (GW-501516) Dosage
Since Cardarine (GW501516) is not FDA-approved, there is no recommended dosage.
For most users, Cardarine is generally taken for 6-8 weeks at a dose of 10-20 mg per day.
Some users might take it both as a capsule and in powder form.
For beginners who are new to the consumption of Cardarine, they mostly started with the dosage of 5 mg-10mg to avoid the side effects.
They might increase the dosage by 5mg after the first month if they didn’t see any kinds of side effects.
There are some users who stack Cardarine with SARMs such as Ostarine, Andarine, Ligandrol, or RAD-140. However, there are unknown side effects associated with these combinations.
Cardarine (GW501516) Before and After Results
Cardarine is best used at a dosage of 15 mg a day for 8 weeks to gain maximum benefit. Some users, however, stacked Cardarine (GW501516) with 10 mg of Ostarine. The combination of the two is usually considered a potent way to burn fat while maintaining muscle mass gains.
Furthermore, Cardarine (GW501516) might help users achieve a leaner physique. Users have reported losing at least 9% of body fat from 15-16% and gaining about 2 pounds of muscle. You will only achieve these results if you follow a careful dietary and training regimen.
Cardarine also offers an amazing endurance benefit for users, which makes workouts and cardio easier. Cardarine has been reported to have healing properties for liver, kidneys, and heart by some users.
Due to its effects, it is quite similar to Stenabolic, except that Cardarine (GW501516) is considered to be more effective for fat loss and boosted endurance.
On the other hand, those who have completed an 8-week cycle of Cardarine with a dosage of 20 mg daily without Ostarine have managed to lose about 5% of body fat while maintaining most of their muscle mass.
However, all these results can only be achieved by following a healthy lifestyle and moderately clean diet in addition to regular strength training sessions.
Cardarine (GW501516) Post Cycle Therapy
Caradarine is not a SARM and it is also non-hormonal, which means that it will not suppress natural testosterone production. This ultimately means that Cardarine does not require PCT (Post Cycle Therapy). There are serious side effects that can result from PCT. A PCT is necessary after a steroid cycle, but not after a SARM cycle.
Where Can You Buy Cardarine (GW501516)?
There are a number of websites that offer Cardarine (GW501516). However, you must make sure that you buy a high-quality one to receive good results and avoid unpleasant side effects.
A number of companies, for instance Brutal Force, offer natural alternatives to SARMs that are really effective.
If you want to get the best results with fewer risks on your health and life, then we recommend buying legal SARMs alternatives.
Furthermore, buying Cardarine (GW501516) from a reputable company is very important to avoid using fakes and bunk products.
Is There Any Legal Alternative To Cardarine (GW501516)?
Cardalean is one of the strongest SARMs that gained popularity as ‘exercise in a bottle’, which was marketed as an alternative to Cardarine.
As legend has it, Cardarine increases metabolism, boosts cardio performance, burns fat, prevents muscle loss, increases a ripped appearance, and basically does everything that requires a caloric deficit.
After reports of uncontrolled cancer growth, including breast cancer and reductions in bone density, the drug was quickly pulled off trials.
It’s appalling how people continue to gamble with their health when Cardalean can produce the same results.
Cardalean targets stubborn fat deposits from multiple angles. The natural ingredients in Cardalean kick start thermogenesis, which increases metabolic activity. It also helps reduce food cravings and accelerate fat loss.
Cardalean contains six natural ingredients that stimulate the release of catecholamines, which promotes fat breakdown, improves mood and focus during exercise, and increases serious muscle gains.
Since Cardarine (GW501516) has already been banned for any form of unprescribed human consumption, we will never recommend it to anyone.
Cardarine (GW501516) was administered at doses ranging from 2 to 10 mg per day for a period of up to 3 months during the Cardarine research studies.
However, as Cardarine never got approval and clinical research was halted due to its cancer-causing properties, there is no safe dosage.
It was shown that Cardarine caused significant liver damage in subjects with even low levels of liver disease, as well as higher levels of cell death in liver cells.
Since Cardarine has caused cancer in animal studies (the main reason Glaxo Smith Kline and Ligand abandoned further development), human safety standards will never be accepted because of the obvious dangers this compound entails.
Beware of testosterone replacement therapy clinics that minimize the risks and neglect to mention its side effects.
There are a considerable number of clinical studies that indicate the dangers associated with Cardarine (GW501516).
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